To reduce time spent changing bedding in cages, which action would be compliant with both GLPs and animal welfare regulations?

• A. The necessary supplies may be moved from the assigned storage area into the animal room, shortly in advance of the work.
• B. All supplies must be kept in the animal room at all times.
• C. Bedding should be changed only at the end of the study.
• D. Change bedding daily regardless of SOP.

Answer: (A)

Minimizing time in the animal room is about planning the work so animals are disturbed as little as possible while staying compliant with approved procedures. Bringing in only what you need, just before you start, keeps the room orderly, reduces door openings, and limits exposure of animals to handling, noise, and odors. This approach fits GLP requirements for controlled, efficient workflows and supports animal welfare by minimizing stress and disruption during routine tasks like bedding changes.

Keeping all supplies inside the animal room would increase clutter and the time animals are exposed to human activity. Waiting to change bedding until the end of the study could unnecessarily prolong disturbance and stress for the animals. Changing bedding daily regardless of the SOP could create unnecessary handling and may not be required by the protocol, increasing disruption without added benefit.